摘要
BCL 2蛋白抑制细胞凋亡是肿瘤发生和产生耐药的重要原因之一。本文通过综述BCL 2蛋白的抗凋亡机制、结构与功能、基于bcl 2基因的肿瘤反义治疗研究成果 ,阐明BCL
It was found that apoptotic pathway blocked by BCL 2 protein was one of the important reasons of tumorigenesis and multi drug resistance in cancer treatment.In this paper,BCL 2 protein was illustrated as a new target that anticancer drugs react through analysing the antiapoptotic mechanism of BCL 2,the relationships between BCL 2 protein structure and its function and the results of antisense therapy based bcl 2 gene.The feasibility of developing small molecule inhibitor of BCL 2 protein was also studied.
出处
《中国药物化学杂志》
CAS
CSCD
2001年第2期115-119,共5页
Chinese Journal of Medicinal Chemistry
基金
国家杰出青年科学基金! (3982 51 2 7)
国家高技术发展计划 (863)基金资助项目! (1 0 3 1 3 0 3 0 8)
