肺癌患者红细胞免疫功能与外周血T淋巴细胞亚群的改变及其临床意义

Changes of erythrocytic immune function and T lymphocyte subsets of peripheral blood in patients with lung cancer and then clinical significance

目的 :观察肺癌患者红细胞免疫功能及T淋巴细胞亚群的变化。方法 :检测 55例肺癌患者进行红细胞免疫功能及T淋巴细胞亚群检测 ,并与 1 5例肺良性肿瘤患者和 2 0例正常人对照。结果 :( 1 )肺癌组红细胞C3b受体花环率 (RBC -C3brecepforrosette,RR)、CD3 + 、CD4 + 、CD8+ 、CD4 + /CD8+ 比值低于正常人 (P <0 0 5) ,红细胞免疫复合物花环率 (RBC -1CR)依次高于肺良性肿瘤组、正常人 (P <0 0 5)。 ( 2 )Ⅲa、Ⅲb期肺癌 ,RBC -C3bRR、CD3 + 、CD4 + 、CD4 + /CD8+ 比值低于Ⅰ、Ⅱ期肺癌患者、正常人 (P <0 0 5) ,而RBC -1CR高于正常人 (P <0 0 1 )。Ⅰ、Ⅱ期病人CD3 + 、CD4 +、CD8+ 低于正常人 (P <0 0 1 ) ,RBC -1CR高于正常人 (P <0 0 1 )。结论 :肺癌患者RBC免疫和T细胞亚群的测定 ,对肺癌的诊断、治疗及病情预后估计有一定价值。

Objective:To study the changes of erythrocytic immune function and T lymphocyte subsets in lung cancer patients.Methods:Erythrocyte immune functions and T lymphocyte subsets were detected in 55 cases of lung cancer;15 cases of lung benign neoplasm and 20 healthy persons were chosen as control.Results:(1)RRC-C3bRR,CD3 +,CD4 +,CD8 +,CD4 +/CD8 + ratio of lung cancer patients were significantly lower than those of healthy group( P <0 05);however RBC-1CR of lung cancer patients were significantly higher than those of lung benign neoplasm and healthy group( P <0 05) in turn.(2)RBC-C3bRR,CD3 +,CD4 +,CD4 +/CD8 + ratio of Ⅲa,Ⅲb staged lung cancer patients were significantly lower than those of Ⅰ,Ⅱ stages and healthy group ( P <0 05);RBC-1CR of Ⅲa,Ⅲb stage in lung cancer patients was significantly higher than those of healthy group( P <0 01),CD3 +,CD4 +,CD8 + of stage Ⅰ,Ⅱ patients were significantly lower than those of healthy group( P <0 01),and RBC-1CR of stage Ⅰ,Ⅱ patlents was significantly higher( P <0 01).Conclusion:Detection of erythrocyte immune functions and T lymphocyte subsets may be useful in the diagnosis,treatment and prognos is of lung cancer.