摘要
测定了8种抗菌药对临床分离的50株厌氧菌的MIC,结果显示克林霉素、林可霉素、甲硝唑和拉氧头孢对革兰氏阴性厌氧杆菌的抗菌活性最强,其MIC为0.125~1mg/L,其次为阿莫西林/克拉维酸和红霉素(MIC为0.25~8mg/L)。它们对革兰氏阳性厌氧杆菌(包括丙酸杆菌和梭菌)及消化链球菌(MIC为0.0625~8mg/L)也有相当的抗菌活性。而青霉素、哌拉西林和头孢他啶抗厌氧菌活性较低,其MIC为8~32mg/L(或u/ml)。
MIC of 8 antimicrobial agents against 50 clinical isolates of anaerobes were determined. Results showed that clindamycin lincomycin, metronidazole and latamoxef had the strongest activities agaist Gram negative anaerobes (MICs range 0.125 ̄1 mg/L), and amoxicilin/clavulanic acid and erythomycin followed (MIC 0.28 ̄8 mg/L), these agents showed certain activities against Gram positive anaerobes (including propionibacterium and clostridium spp), and peptostreptococcus (MICs range 0.625 ̄8 mg/L). But antibiotic activities of penicillin、ceftazidime and piperacillin were weaker, their MICs range from 8 to 32mg/L.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1999年第1期28-31,共4页
Chinese Journal of Antibiotics
关键词
厌氧菌
敏感试验
最低抑菌浓度
Anaerobes
Sensitivity test
Minimal inhibitory concentration (MIC)