8种抗菌药对临床分离的厌氧菌敏感性试验的研究

Sensitivity study of eight antimicrobial agents to clinical anaerobe isolates

测定了８种抗菌药对临床分离的５０株厌氧菌的ＭＩＣ，结果显示克林霉素、林可霉素、甲硝唑和拉氧头孢对革兰氏阴性厌氧杆菌的抗菌活性最强，其ＭＩＣ为０．１２５～１ｍｇ／Ｌ，其次为阿莫西林／克拉维酸和红霉素（ＭＩＣ为０．２５～８ｍｇ／Ｌ）。它们对革兰氏阳性厌氧杆菌（包括丙酸杆菌和梭菌）及消化链球菌（ＭＩＣ为０．０６２５～８ｍｇ／Ｌ）也有相当的抗菌活性。而青霉素、哌拉西林和头孢他啶抗厌氧菌活性较低，其ＭＩＣ为８～３２ｍｇ／Ｌ（或ｕ／ｍｌ）。

MIC of 8 antimicrobial agents against 50 clinical isolates of anaerobes were determined. Results showed that clindamycin lincomycin, metronidazole and latamoxef had the strongest activities agaist Gram negative anaerobes (MICs range 0.125￣1 mg/L), and amoxicilin/clavulanic acid and erythomycin followed (MIC 0.28￣8 mg/L), these agents showed certain activities against Gram positive anaerobes (including propionibacterium and clostridium spp), and peptostreptococcus (MICs range 0.625￣8 mg/L). But antibiotic activities of penicillin、ceftazidime and piperacillin were weaker, their MICs range from 8 to 32mg/L.