单剂头孢曲松预防肺手术后感染

Prophylactic Uses of Single Dose Ceftriaxone in Pulmonary Surgery

目的 比较预防性使用单剂头孢曲松和四剂头孢曲松对肺手术后感染的效果 ,论证单剂头孢曲松预防方案的临床价值。 方法 2 2 3例肺手术患者随机分成单剂头孢曲松组 (单剂组 ,n=110 )和四剂头孢曲松组 (四剂组 ,n=113)进行临床对照研究。 结果 单剂组的术后感染率 (2 % )明显低于四剂组 (8% ) ,差别具有显著性意义 (P<0 .0 5 ) ,而两组的平均住院时间和平均术后住院时间差别均无显著性意义 (P>0 .0 5 )。

Objective To compare the efficacy of single dose with four doses of ceftriaxone as infection prophylaxis in pulmonary surgery, and to assess the value of single dose ceftriaxone regimen. Methods Two hundred and twenty-three patients were divided randomizedly into single dose ceftriaxone group(n=110) and four dose ceftriaxone group(n=113) for a clinical controlled study. Results A significant lower incidence of postoperative infections occured in single dose ceftriaxone group (2%) compared with four dose ceftriaxone group (8%). There was no significant difference in hospital stay between single dose ceftriaxone group and four dose ceftriaxone group(P>0.05). Conclusion Single dose ceftriaxone may be a better prophylactic regimen of postoperative infection for patients undergoing pulmonary surgery.