猪异位部分肝移植的血液动力学变化

Changes of hemodynamics during heterotopic partial liver transplantation in pigs

目的 探讨猪异位部分肝移植术中血液动力学的变化。方法 10头幼猪随机分成供体组 (5只 )和受体组 (5只 ) ,受体猪参照Terpstra的方法进行异位部分肝移植。受体猪右颈外动脉置管监测术中动脉压 ,经右颈外静脉放置 5FSwan -Ganz导管监测术中血液动力学参数。结果 异位部分移植术中心输出量及每搏量、外周血管阻力均有显著改变 (P<0 0 1或P <0 0 5 ) ) ;虽有血压下降 ,心率增快 ,但无显著意义 (P >0 0 5 )。肺动脉楔嵌压、平均肺动脉压无显著变化 (P >0 0 5 )。结论 异位肝移植术中血液动力学可发生剧烈波动 ,血液动力学的监测及调节十分重要。

Objective To study the changes of hemodynamics during heterotopic partial liver transplantation (HPLT) in pigs. Methods 10 young pigs after intravenous anesthesia were divided into two groups: donor group (5 pigs) and recipient group (5 pigs). In recipient pigs, a catheter inserted to right cervical artery was used to monitor artery bood pressue, and Swasn-Ganz catheter inserted via right cervical vein was used to monitor hemodynamics during operation.Results There were significant changes in CO, SV and SVR (P<0.01 or P<0.05); although decreasing in MAP and increasing in HR occurred during operation, but no significance(P>0.05) was found. There were no significant changes in PCWP and PAP during HPLT (P>0.05). Conclusions There is significant hemodynamic fluctuation during HPLT. It is very important that to monitor hemodynamics, prevent and manage hemodynamics disturbance durig HPLT