精神分裂症患者攻击行为与体感诱发电位

Relationship between compulsive aggression and abnormal somatosensory evoked potentials in schizophrenia

目的 :探讨体感诱发电位 (SEP)异常与精神分裂症患者冲动性攻击行为的关系。 方法 :以既往史和外显攻击行为量表 (MOAS)评分区分冲动性暴力攻击组 (研究组 )与无暴力攻击组(对照组 ) ,比较两组的 SEP各主要成分 ,并对 SEP与精神症状、攻击行为亚型之间的相关性进行检验。 结果 :研究组在各脑区的 SEP- P2 潜伏期均较对照组明显缩短 ;而波幅仅在 Cz脑区有明显增高。潜伏期缩短与情感淡漠或无关 ,以及外向性攻击行为有显著性相关 ;波幅增高则与言语攻击等程度较轻的攻击行为有关。 结论 :SEP潜伏期缩短与波幅增高可能与精神分裂症患者的攻击行为有关。

Objective:To investigate the relationship between somatosensory evoked potentials (SEP) abnormality and aggerssive behavior in schizophrenias. Method:According to the past violence history and ratings on MOAS,67 schizophrenic patients were divided into research and control groups respectively.Components of SEP were compared between the two groups,and correlation of SEP with BPRS and MOAS sub-scales were also built up. Results:Overt aggressive subjects had significant reduction in SEP-P2 latency,while increase in amplitude.SEP latency reduction was significantly correlated with emotional indifference and extraversion aggression,but increased SEP amplitude related to mild aggressive behavior. Conclusion:Reduced latency and increased amplitude in SEP may be related to the violent behavior in schizophrenia.