肝素钙预防过敏性紫癜患儿肾损害临床观察与分析

Clinical observation and analysis of heparin calcium as a precaution against kidney involvements in Henoch Schonlein purpura patients

目的 探讨过敏性紫癜患儿应用肝素钙预防肾损害的有效性、可行性。方法 将 5 9例过敏性紫癜患儿随机分成肝素钙治疗组和对照治疗组 ,另设非HSP对照组 2 0例 ,追踪监测尿 β2 微球蛋白 (β2 M )、尿微量白蛋白 (Alb)。结果 两组在治疗前尿 β2 M和尿Alb差异无显著性 (P >0 0 5 ) ,治疗后 3个月、6个月肝素钙治疗组尿 β2 M和尿Alb低于对照治疗组 ,差异有显著意义 (P <0 0 1)。肝素钙治疗组 6个月后尿Alb与非HSP组相比差异无显著性 (P >0 0 5 )。结论 肝素钙可有效地预防过敏性紫癜肾损害 。

Objective To explore the effectivity and feasibility of heparin calcium as a precaution against kidney involvements in Henoch Schonlein purpura patients.Methods The 59 HSP patients were divided into the heparin calcium treated group and the control group at random.β 2 M and Alb of urine were monitored constantly. Results No significant differences were found between the two groups in β 2 M and Alb of urine before treatment(P>0 05).The two indexes of the heparin calcium treated group were lower than that of the control group after 3 and 6 months’ treatment,and significant differences could be observed(P<0 01).As to Alb of urine,there were no significant differences between the heparin calciunm treated group and the non HSP group after 6 months’ treatment(P>0 05). Conclusions Heparin calcium can be used to protect against kidney involvements in HSP patients safely.