骨形成蛋白(BMP-5)与IA型BMP受体在口腔鳞癌中的表达及意义

Expression of BMP-5,BMPR-IA in Squamous Cell Carcinoma of Oral Epithelium

目的 认识和分析 BMP及其受体 BMPR- IA与口腔鳞癌发生、发展的可能关系。方法 用免疫组织化学方法分析 BMP- 5、BMP受体 BMPR- IA在口颊部粘膜正常上皮、慢性炎症和癌变中的表达 ,标本为 18例正常上皮(normal buccal mucosa,NB) ,2 4例慢性炎症 (nonspecofic chronic inflammation.NCI) ,5 8例鳞癌 (squamous cellcarcinoma,SCC)。结果 BMP- 5、 BMPR- IA在口腔粘膜的正常与慢性炎症上皮中有弱表达 ,NB与 NCI无明显差别 ;在鳞癌上皮中除 2例 BMP- 5表达为阴性外 ,其余均有阳性或强阳性表达 ,明显高于 NB、NCI两组 ;鳞癌中高分化、中分化、低分化三组间的表达无明显差别。结论 BMP- 5、 BMPR- IA可能参与对口腔鳞癌发生。

Objective:To study the relationships between bone morphogenetic proeins(BMPs),BMP receptor type IA and squamous cell carcinoma of oral epithelia.Methods:Expressions of BMP 2/4,BMPR IA were analyzed the specimens obtained from buccal mucosa,including 18 case of normal mucosa(NB),24 case of chronic inflammation(NCI) and 58 case of squamous cell carcinpma(SCC) with immunohistochemisty.Result:The immunostaining of BMP 5,BMPR IA was weak and not altered apparently in normal and chronic inflammation groups,Except for 6 case of SCC showed not positive staining for BMP 5,all case of SCC showed positive staining for BMP 5,BMPR IA.The proportion of the positively stained cells in SCC were markly in creased than that in normal and chronic inflammation groups,expressions of BMP 5,BMPR IA were not altered apparently in SCC1,SCC2,SCC3 groups.Conclusion:BMP 5,BMP IA might be involved in occurrence and development of squamous cell carcinoma of oral epithelium.