盐酸丁咯地尔治疗急性脑梗死临床观察

Clinical Observation of Buflomedil Hydrochloride in Treatment of Acute Cerebral Infarction

目的:观察盐酸丁咯地尔治疗急性脑梗死的临床疗效及安全性。方法:设立盐酸丁咯地尔治疗组及低分子右旋糖酐加复方丹参对照组。治疗前后检测血液流变学及采用神经功能缺损和生活能力状态量表评分进行疗效判定。结果:治疗组总有效率90.7％,高于对照组的68.9％。治疗组血液流变学改善,神经功能缺损评分减少,与对照组比较均有显著性差异(P<0.05)。结论:盐酸丁咯地尔治疗急性脑梗死有较好疗效,副作用少而轻。

Objectives: To observe the clinical effect and safety of buflomedil hydrochloride in the treatment of acute cerebral infarction. Methods: Two groups were established, the buflomedil hydrochloride group was treated group, dextran 40 plus Salvias miltiorrhiza Co. was served as controlled group. The clinical effects were evaluated by the test to changes of the hemastatics before and after treatment and by the judgements on nervous hypofunction and living-ability status scales. Rusults: The improvement of hemastatics of the treated group was significantly higher than that of the controlled group(P<0.05). The scale of nervous hypofunction was significantly decrease in the freated group (P < 0. 05). The effective rate of the treated group was 90. 7 % , being higher than that of the controlled group(68.9 % ). Conclusions: There was a better clinical effect with buflomedil in the treatment of acute cerebral infarction less the side effects were less and slighter.