枸橼酸杆菌致小儿腹泻临床流行病学研究

The epidemiological study on citrobacter enteritis in children

目的 :探讨枸橼酸杆菌肠炎的发病情况及相关因素。方法 :对腹泻组患儿 2 196例 ,应用抗生素 ,非腹泻对照组(患其它疾病 )患儿 40 0例 ,应用抗生素 ,健康对照组 40 0例 ,均进行枸橼酸杆菌检出率、药敏试验、临床特征等比较。结果 :腹泻组患儿的枸橼酸杆菌检出率为 5 87% ,明显高于非腹泻组、对照组 ,且与年龄、季节、喂养方式等有一定相关性。但临床症状及实验室常规检查缺少特异性。药敏试验结果对丁胺卡那霉素、喹喏酮类药物敏感 ,而对头孢菌素类及氨苄青霉素等耐药。结论 :枸橼酸杆菌肠炎在各类腹泻患儿中占较高比例 ,且以 <1岁人工或混合喂养儿及夏秋季节多发 。

Objective To investigate the morbidity and correlated factors on citrobacter entritis in children.Methods The detectable rate of citrobacter, drug sensitive test and clinical features were compared in the following three groups: dairrhea group(2196 cases), no diarrhea but with other diseases group (400 cases) and control group (400 cases). Results The detectable rate of citrobacter was 5.87%, obviously higher than the other three groups. Citrobacter was correlative to season, age and feeding form. But the clinical symptoms and lab routine examinations showed no specifictity. Drug sensitive test indicated citrobacter was sensitive to Amikacin and Quinoxaline, but was drug-resisitant to Cephalosporin and Amipicillin. Conclusions The morbidity of citrobacter enteritis is the highest in diarrhea children and frequently occurs in summer and autumn in artificial or mixed feeding babies who were younger than one year.