女阴假性湿疣病因探讨

Pathogenetic analysis on pseudocondyloma of vulva

目的 探讨女阴假性湿疣致病因素。方法 对 32 1例女性下生殖道赘生物患者的一般情况、病史、皮损的形态特征及实验室检查、组织病理、免疫组化、PCR检测结果等进行分析。结果 女阴假性湿疣患者绝大多数无不洁性接触史 ,临床症状以白带增多为主。阴道镜下观察 :赘生物多为颗粒状、指状 ,大小均一 ,分布对称。组织病理 :表皮有少许典型空泡样细胞。免疫组化 :HPV Ag(- )。A组PCR检测HPVs阳性率为 12 79%。 结论 女阴假性湿疣为一种非性传播性疾病 ,与HPVs感染无相关性。

Objective To investigate the pathogenesis of pseudocondyloma of vulva.Methods 321 cases of neoplasms in lower female genital tract were divided into two groups.We determined multiple factors for all the cases.Results The majority of the patients in group A had no histories of illegal intercourses.Their leukorrhea was obviously increased.The appearance of neoplasms showed in granular or finger shape.Histopathology showed that koilocyte-like cells could be seen without diagnostic koilocytes.Most of the cases were HPV-Ag negative.22 cases were HPVs-DNA positive(positive rate 12 79%) with polymerase chain reaction.Conclusion Pseudocondyloma of vulva is a non-sexually transmitted disease which has no relations with HPVs infection.