老年高血压病并发脑梗死患者内皮细胞损伤和血小板活化的研究

Study on endothelial dysfunction and platelet activation in elderly hypertensive patients complicated with cerebral infarction

目的 :研究老年高血压病并发脑梗死患者、老年高血压病患者的内皮细胞损伤、血小板活化和炎症因子改变。方法 :选择 2 8例老年高血压病并发脑梗死患者 (发病 72h内 )、31例Ⅰ ,Ⅱ期老年高血压病患者和 2 8例老年正常对照 ,测定其血浆vonWillebrand因子 (vWF)、α颗粒膜蛋白 - 140 (GMP 140 )和血清C反应蛋白 (CRP)含量。结果 :老年高血压病并发脑梗死组血浆vWF含量、GMP 140含量和血清CRP含量均明显高于老年高血压病组及老年正常对照组 ;老年高血压病组血浆vWF含量、GMP 140含量亦明显高于老年正常对照组 ,血清CRP含量较老年正常对照组高 ,但差异无显著性。结论 :老年高血压病并发脑梗死患者存在明显的内皮细胞损伤、血小板活化和炎症改变 ;Ⅰ ,Ⅱ期老年高血压病患者亦有明显的内皮细胞损伤和血小板活化。

Objective The aim of this paper was to investigate endothelial dysfunction,platelet activation, and inflammation in elderly hypertensive patients and those complicated with cerebral infarction. Methods Twenty eight elderly hypertensive patients complicated with cerebral infarction(within 72 hours after onset of neurological symptoms),thirty one Stage Ⅰ～Ⅱelderly hypertensive patients and twenty eight elderly healthy individuals were selected as subjects.Their plasma concentrations of von Willebrand factor(vWF), alpha granule membrane protein 140(GMP 140), and serum concentrations of C reaction protein(CRP) were examined. Results Elderly hypertensive patients complicated with cerebral infarction had significantly higher plasma vWF, GMP 140, and serum CRP than elderly hypertensive patients and elderly healthy individuals. Plasma vWF and GMP 140 were higher in elderly hypertensive patients than elderly healthy individuals, whereas serum CRP was increased slightly and there was no significant difference between elderly hypertensive patients and elderly healthy individuals. Conclusion This study suggests that elderly hypertensive patients complicated with cerebral infarction have obvious endothelial dysfunction, platelet activation, and inflammatory change. Stage Ⅰ～Ⅱ elderly hypertensive patients have obvious endothelial dysfunction and platelet activation as well.