病理性近视眼患者血清的羟脯氨酸浓度改变

The Increased Level of Serumal Hydroxyproline in Chinese Pathologic Myopes

目的 了解病理性近视眼患者是否存在全身性胶原代谢改变。方法病理性近视眼患者２５例，正视眼对照２３例，取晨间空腹静脉血的血清，以盐酸水解后按氯胺Ｔ氧化比色法测羟脯氨酸浓度。结果病理性近视眼组血清羟脯氨酸浓度为（２５．０８４±６．９９６）μｇ／ｍｌ，对照组为（１８．２８６±３．４１７）μｇ／ｍｌ，有显著性差异（非参数检验，Ｐ＜０．００１）。病理性近视眼患者血清的羟脯氨酸浓度与近视程度无显著相关性（Ｐ＞０．０５）。结论 部分病理性近视眼患者可能存在着全身性的胶原代谢异常。

ObjectiveTo investigate whether systemic disturbance of collagen metabolism occurred in human pathologic myopia.MethodsThe serumal hydroxyproline of pathologic myopes(n=25)and emmetropes(n=23)was measured using chloramine T following hydrolysis of 6 mol/L HCl.ResultsThe level of serumal hydroxyproline was significantly higher within pathologic myopes[(25.084±6.996)μg/ml]compared with emmetropes[(18.286±3.417)μg/ml, P<0.001],whereas no significantly correlation was found in hydroxyproline level and myopic degrees(r=-0.214,P>0.05).Conclusion Systemic anomaly of collagen metabolism may play an important role in the pathogenesis of pathologic myopia.