烧伤早期切痂对大鼠心肺血管通透性影响

Effects of early postburn escharectomy on the permeability of cadiac and pulmonary blood vessels in rats

目的 探讨烧伤早期切痂对脏器血管通透性的影响 ,阐明烧伤早期切痂对脏器功能损害的防治作用。方法 Wistar大鼠随机分为烧伤组 (A) ,早期切痂组 (B)及正常对照组 ,采用99锝标记白蛋白测定心、肺血管通透性变化 ,同时 ,对比早期切痂组血清对体外培养内皮细胞单层通透性影响。结果 大鼠严重烧伤后心、肺血管通透性增加 ,B组血管通透性较A组降低 ;B组烧伤血清较A组烧伤血清可降低体外培养内皮细胞单层通透性的增加。结论 烧伤早期切痂植皮有利于降低烧伤后脏器血管通透性的增加。

Objective To evaluate the prophylactic-therapeutic role of escharectomy during early postburn stage on internal organ dysfunction. Methods A total of 72 Wistar rats were randomized into 3 groups: burn without escharectomy group (A group), burn with escharectomy during early postburn stage (B group) and normal control. Vascular permeability were measured with 99Tc-labelled albumin. Furthermore, the effect of burn sera on permeability of monolayer of vascular endothelial cell (EC) was observed. Results Vascular permeability in group B was significantly lower than in group A. When exposed to burn sera, EC monolayer permeability in group B is decreased when compared with group A. Conclusion Escharectomy during early postburn stage could restore endothelial permeability