猪单纯门静脉血流阻断对肠粘膜通透性影响的研究

Effect of portal vein blocking on permeability of the intestinal mucosa in pigs

目的 研究猪单纯门静脉血流阻断对肠粘膜通透性的影响。方法 将健康荣昌种猪随机分为假手术组 (SO)、单纯门静脉阻断 45min(PVC 45’)、60min(PVC 60’)组 ,进行门静脉血流阻断后 ,测定每组的尿中乳果糖 (L)、甘露醇 (M)排出率比值 (L/M )。结果 PVC 45’、60’组L/M均明显高于SO组 (P <0 .0 5 ) ;而PVC 60’略高于PVC 45’组 (P >0 .0 5 )。

Objective To study the effect of portal vein blocking on the permeability of the intestinal mucosa in pigs. Methods Healthy Rongchang pigs were divided into 3 groups: ① sham operation group(SO), ② portal vein clamping for 45 min group (PVC-45'), ③ portal vein clamping for 60 min group (PVC-60'). Urine lactulose/mannitol(L/M) ratio was measured after portal vein blocking. Results The L/M ratio was increased significantly (P<0.05) in PVC-45' and 60' groups than in SO group, with that of PVC-60' higher than that of PVC-45' group, but not significantly. Conclusion The increase of intestinal mucosal permeability after portal vein blocking is an early and important index for the damage of the intestinal mucosa barrier.