急性胰腺炎促炎因子和抗炎因子变化的动态观察

Dynamic changes of pro-and anti-inflammatory cytokines in acute pancreatitis

目的 探讨促炎细胞因子和抗炎细胞因子在急性胰腺炎 (AP)发病过程中动态变化的意义。方法 应用ELISA法检测 48例病人血液中促炎细胞因子 (TNFα、IL 1β、IL 6、IL 8)和抗炎细胞因子 (IL 10、IL 1ra)。 结果 AP病人血液中促炎细胞因子和抗炎细胞因子在早期持续显著升高 (与正常对照组相比P <0 .0 5 ) ,其后逐渐下降 ,并与临床症状变化的时相一致。

Objective To explore the significance of the dynamic changes of pro-and anti-inflammatory cytokines in the onset and development of acute panreatitis (AP). Methods Pro-inflammatory cytokines TNFα, IL-1β, IL-6, and IL-8 and anti-inflammatory cytokines IL-10 and IL-1ra in the plasma of 48 patients with AP and 20 healthy individuals were determined with ELISA. Results The levels of all pro-and anti-inflammatory cytokines in plasma was significantly higher in AP patients than in control group (P<0.05) in early stage of the disease, and then all levels were decreased gradually, consistent with the alterations of clinical symptoms of the AP patients. Conclusion The dynamic changes of pro-and anti-inflammatory cytokines might play important role in the onset and development of AP.