伴嗜酸性粒细胞增多性血管淋巴样增生的临床病理分析

Clinicopathological analysis on angiolymphoid hyperplasia with eosinophilia

目的 探讨伴嗜酸性粒细胞增多性血管淋巴样增生的临床病理学特征。方法 对我科 195 0～ 1999年期间所诊治的伴嗜酸性粒细胞增多性血管淋巴样增生的 7名患者的病理标本重新切片 ,进行病理学上的分析。结果 伴嗜酸性粒细胞增多性血管淋巴样增生在病理学上有其特征 ,形态学上的改变主要表现在以下 3个方面 :①真皮内大量毛细血管增生 ;②血管内皮细胞增生肿大 ,似“墓碑”状突入血管腔 ;③病变处有淋巴细胞、嗜酸性粒细胞混合浸润。结论 伴嗜酸性粒细胞增多性血管淋巴样增生是一种良性局限性血管增生 ,其病因及发病机制尚不清楚。熟悉这一疾病的组织学改变对避免误诊为其他类似疾病有重要意义。

Objective To analyze the clinicopathological features of angiolymphoid hyperplasia with eosinophilia (ALHE). Methods The pathological specimens of 7 cases of ALHE collected in our department from 1950 to 1999 were sectioned, stained and observed. Results There were 3 pathological characteristics in ALHE: ①massive hyperplasia of capillaries in the dermis; ②the endothelial cells proliferated and swelled, projecting into vascular cavity like tombstones; ③mixed infiltration of lymphocytes and eosinocytes in the vessels. Conclusion ALHE is a disease with local benign proliferated vessels, whose etiology and pathogenesis is still unknown. It is necessary to grasp the pathological changes of ALHE to distinguish it from other diseases.