喹乙醇在肉鸡体内的代谢动力学研究

Studies on Pharmucokinetics of Olaquindox in Broiters

本文选用高效液相色谱(HPLC)法为定量手段研究了喹乙醇在肉鸡体内的代谢动力学过程。口服喹乙醇后,肉鸡血清药物浓度——时间曲线符合开放式二室模型。其药动学参数,药物的分布相半衰期(t1/2α)为1.56(hr),消除相半衰期(t1/2β)为2.53(hr),曲线下面积(Auc)为218.7,达峰时间为1.55(hr)。

Pharmacokinetics processes of olaquindox in broiters are studied by using the HPLC procedure. The blood concentration-trine course conforms to the two compartment open model after broiters dre dosed with oraquindox. The primary kinetic parmameters are as fallows, the distributed halflife (t1/2α) is 1.56 (hr), the elimination half-llfe (t1/2β) is 2.53 (hr), the area under the curve(AUC) is 218.7 and the peak time is 1.55 (hr).