烯效唑(Uniconazole)立体异构体的有择合成研究

Studies on Stereospecific Synthesis of Optical Isomers of Uniconazole

对烯效唑立体异构的有择合成进行了探讨，试验结果表明，选用适宜的还原剂可实现烯效唑立体异构体的优势合成，获得高纯高活性的Ｅ—Ｒ，Ｅ—Ｓ结构的烯效唑。

This paper discussed the stereospecific synthesis of uniconazole stereomers.The experiment results have proved that (E)-1-(4-chlorophenyl)-2-(1,2,4-triazol-1-yl)-4,4-dimethye-1-penten-3-one is reduced to uniconazole,with potassium borohydride as reductant,the yield is over 99%,and the 96% of product is E-R isomer,only 4% E-S isomer. With butyl magnesium bromide (Grignard reagent) as reductant,the yield is only 47.8%,the product is all E-S uniconazole.The conclusion is that the superior synthesis of E-R and E-S uniconazole stereomers can be realized by selecting suitable reductants.