人尿中克罗帕米的GC/MSD检测方法研究

Determination of Clopamide in Human Urine by GC/MSD

建立了人尿中克罗帕米的GC/MSD的检测方法 ,发现了三种甲基化产物。比较了不同的提取方法 ,碱性提取收率可达 94 5 %。

Clopamide as a new diuretic was forbidden by IOC.A new reliable GC/MSD determination method of clopamide in human urine is described in this paper.Three methyled compounds are found and varieties of extraction procedures are compared.The basic extraction recovery is 94.5%. The excretion profile of clopamide in human urine has been investigated.Clopamide could be detected in human urine within 20 hours.