摘要
系统地介绍和评述了近年来氨基、羧基、巯基和羟基等基团的酶催化脱保护方法的进展.由于酶催化脱保护方法具有反应条件温和(中性,水溶液)、选择性和专一性高、副反应少等优点,故在多肽缀合物、糖等敏感多官能团化合物的研究中有很广阔的应用前景.
Recent advances in enzymatic deprotection reactions of amino groups, carboxyl groups, thiol groups and hydroxyl groups are reviewed. Enzymatic deprotection techniques, which have the advantages of high selectivity, high specificity under mild conditions and in aqueous solutions, are being evaluated as potential methods for synthesizing the sensitive compounds such as peptide conjugates and carbohydrates.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2001年第4期273-277,共5页
Chinese Journal of Organic Chemistry