IgG类HBsAg循环免疫复合物在各类乙型肝炎肝损害中的意义

ROLE OF CIRCULATING HBSAG IMMUNE COMPLEXES OF IGC CLASS IN THE DAMAGE PROCESS OF LIVER IN DIFFERENT CLINICAL TYPES OF HEPATITIS B INFECTION

本文对五类205例乙型肝炎患者血清标本并行检测IgG类HBsAg循环免疫复合物和血清谷丙转氨酶(SGPT)。结果表明,205例乙型肝炎患者IgG类HBsAg循环免疫复合物的检出率与SCPT的变化无明显关系。但按临床类型分析发现,急性乙型肝炎、慢性迁延性乙型肝炎及乙型肝炎后肝硬化IgG类HBsAg循环免疫复合物的检出率在SGPT正常和异常者中无明显差异;而在慢性活动性乙型肝炎和重症乙型肝炎中SGPT异常者IgG类HBsAg循环免疫复合物的检出率均显著高于SGPT正常者。提示IgG类HBsAg循环免疫复合物在后两类乙型肝炎的肝损害过程中起重要作用。同时还说明,分型分析对研究乙型肝炎具有重要意义。

In this paper,the relationship is analysed between the positive rates of circulatiug HBsAg immune complexes of IgG class and SGPT in 205 cases of clinical types of hepatitis B infection.It was found that the positive rates of HBsAg/IgG—CIC had no significant difference between normal SGPT and abnormal SGPT groups of 205 cases.If clinical types of hepatitis B infection were considered,the positive rates of HBsAg/IgG—CIC were significant higher in abnormal SGPT cases than in normal ones in chronic active hepatitis B and severe hepatitis B but were not in acute hepatitis B, chronic persistent hepatitis B and cirrhosis after hepatitis B.The results suggest that HBsAg/IgG—CIC plays an important role in the damage pro- cess of liver of chronic active hepatitis B and severe hepatitis B and that analysis according clinical types is very important to study hepatitis B.