佩尔地平缓释剂对肾移植病人环孢霉素A代谢的影响

Effect of Perdipine LA on Cyclosporine A metabolism in renal transplant patients

目的 :研究 8名肾移植并发高血压症患者 ,接受药物环孢霉素A(CsA)和新型钙通道阻滞剂佩尔地平 ( perdipine)缓释胶囊治疗。方法 :在肾移植术后第 3周开始口服佩尔地平 ,同时监测病人CsA血药浓度、血清肌酐值。结果 :8名病人中 7名CsA血药浓度、血清肌酐值显著升高。停用佩尔地平后 ,CsA血药浓度、血清肌酐值恢复到原有水平。结论 :提示佩尔地平影响CsA的代谢 ,在停药后 ,此拮抗作用可逆转。因此 ,肾移植病人服用钙通道阻滞剂应注意监测CsA血药浓度。

OBJECTIVE To study the Perdipine LA treatment for 8 renal transplatation patients with hypertension.METHODS Perdipine LA was given at the third week post transplanation,Cyclosporine A (CsA) plasma levels and serum creatinine were measured.RESULTS CsA plasma levels and serum creatinine increased by perdipine and returned to pretreatment levels after discontinuing the use.CONCLUSIONS These data suggest that Perdipine LA interferes with CsA metabolism and this interaction is reversible after Perdipine discontinued.These findings point out that calcium channel blockers need to be cautiously used in patients receiving CsA.