碳纤维增强的聚醚醚酮复合材料椎体间植入的实验研究

Experimental study of interbody fusion using CFR/PEEK

目的 :研究碳纤维增强的聚醚醚酮复合材料 (CFR/PEEK)椎间植入后 ,在骨组织内的生物相容性及在椎间融合术中的作用。方法 :选取 13只 Beagle狗 ,分为 2组。实验组 7只狗 L6～ 7椎间植入盘状带孔 CFR/PEEK;对照组 6只狗 ,相同位置植入环氧乙烷处理的冷冻异体骨。分别于术后 6、12和 2 4个月行 X线片、螺旋 CT(QCT)扫描及病理检查。结果 :X线、QCT及病理检查三者对椎间融合判断的符合率为 10 0 %。术后 12个月 ,实验组的融合率高于对照组 ;术后 2 4个月 ,两组均全部融合。病理检查显示复合材料前方的软组织为非特异性的纤维结缔组织 ,碳微粒见于其周围组织内 ,细小微粒被异物巨细胞吞噬。骨磨片显示新骨组织长入复合材料的小孔内 ,碳微粒对骨组织无明显影响。 结论 :CFR/PEEK对骨组织有良好的相容性。

Objective: To study the biocompatibility of CFR/PEEK composite in bone tissue after implanted in lumbar intervertebral space and to evaluate its role in the interbody fusion compared to the allograft bone. Methods: Thirteen beagles were chosen among which 7 were implanted with the disk like CFR/PEEK composite in the lumbar intervertebral space and the other 6 were implanted with allograft bone. X ray, QCT and histological examination were employed at 6, 12 and 24 months postoperatively. Results: The X ray results of fusion segment were in conformity with the QCT's as well as that of histological results. All animals obtained a complete fusion at 24 months. Histological examination revealed that the anterior soft tissue to the implant exhibited a nonspecific foreign body reaction with connective tissue embed the biomaterials. Carbon fragment were seen in the surrounding tissue and some of the debric were phagocytosed by foreign body giant cell. Histological examination of bone and material revealed that new bone grew along the hole of CFR/PEEK implant. Conclusion: CFR/PEEK has an excellent biocompatibility to bone tissue. [