摘要
目的 :观察东莨菪碱 (scopolamine,Spm )和氯丙嗪 (chlopromazine,Clo)对吗啡戒断反应的影响。 方法 :采用吗啡依赖大鼠模型 ,不同剂量单次、多次皮下注射 (sc)东莨菪碱及合并使用氯丙嗪处理动物后 ,腹腔注射 (ip)纳洛酮 5 mg/ kg诱发戒断反应 ,观察戒断症状。 结果 :单次 sc东莨菪碱 1.0 mg/ kg及多次 sc东莨菪碱 0 .5 mg/ kg可明显抑制吗啡依赖大鼠的躯体戒断反应 ,合并注射氯丙嗪 2 0 .0 mg/ kg时的效果更好。结论 :东莨菪碱通过 Ach受体可以抑制吗啡戒断反应 ,氯丙嗪则可能通过作用于蓝斑等中枢部位α2 受体与东莨菪碱起到协同作用。
Objective: To observe the inhibitory effect of scopolamine(Spm) and chlopromazine (Clo) on withdrawal syndromes in morphine dependent rats. Methods: The intensity of withdrawal syndromes on the model of morphine dependent rats was recorded after single or muiltiple subcutaneous administration(sc) of Spm and Clo at different doses. Results: Withdrawal syndromes were markedly decreased when single Spm 1 mg/kg and Clo 0.5 mg/kg combined with morphine were injected ( P <0.05). Spm+Clo(sc) had much stronger effects on inhibiting withdrawal syndromes after intraperitoneal (ip) naloxone in morphine dependent rats ( P <0.01). Conclusion: Spm can act on Ach receptor and relieve morphine withdrawal syndromes. Clo may have a synergistic action with Spm via α 2 receptor in the locus coeruleus of the rat brain stem. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2001年第4期351-353,共3页
Academic Journal of Second Military Medical University
基金
国家自然科学基金!资助项目 (39870 75 7)
