鼻咽癌患者血清新蝶呤、sCD4与sCD8检测的意义

Measurement of Serum Neopterin and Soluble Lymphocyte Antigens(sCD4 and sCD8) in Patients with Nasopharyngeal Carcinoma and Its Clinical Significance

目的 :探讨血清新蝶呤、s CD4及 s CD8分子水平和鼻咽癌的关系及临床意义。方法 :采用EL ISA方法检测 5 4例初治鼻咽低分化鳞癌治疗前、后及 32例健康成人的血清新蝶呤、s CD4与s CD8分子浓度。结果 :鼻咽癌血清新蝶呤、s CD4及 s CD8浓度高于健康对照组 (P<0 .0 0 1 )。不同TNM分期血清新蝶呤、s CD4及 s CD8水平无差异 (P>0 .0 5 ) ;无淋巴结转移者血清新蝶呤低于有淋巴结转移者 (P<0 .0 5 )。治疗后新蝶呤、s CD4与 s CD8水平比治疗前明显降低 (P<0 .0 1 ) ,仍比对照组高 (P<0 .0 1 ) ;治疗后 6月肿瘤全消者继续保持在较低水平 ,肿瘤残留者则回升到治疗前水平 (P<0 .0 1和 0 .0 5 )。结论 :血清新蝶呤、s CD4与 s CD8分子水平检测可作为鼻咽癌病情评估。

Objective:To evaluate the relationship between serum levels of neopterin and sCD4 & sCD8 antigens and nasopharyngeal carcinoma and its clinical significance.Methods:The serum levels of neopterin and sCD4 & sCD8 antigens were determined in 54 patients with nasopharyngeal carcinoma(NPC group) and 32 healthy adults(normal group) by ELISA.Results:The serum levels of neopterin and sCD4 & sCD8 antigens in NPC group were significantly higher than those in normal group( P <0.001).The serum levels of neopterin and sCD4 & sCD8 antigens were not related to UICC TNM stages( P >0.05).The serum neopterin levels in patients without lymph node metastasis were lower than those with metastasis( P <0.05).The serum levels of neopterin and sCD4 & sCD8 antigens decreased significantly after raditoherapy( P <0.01).Conclusion:The measurement of the serum levels of neopterin and sCD4 & sCD8 antigens in patients with nasopharyngeal carcinoma reflects disease status and may be a useful objective index to evaluate cellular immunological functions and curative effects and prognosis.