实验性自身免疫性感音神经性聋的自然演变

Natural development of the experimental autoimmune sensorineural hearing loss

应用粗制内耳抗原（ＣＩＥＡｇ）与等量福氏佐剂（ＣＦＡ；ＩＦＡ）皮下注射兔疫豚鼠４次，复制动物模型。模型动物经过９周自然病程演变后。结果：（１）实验动物内耳病变基本消失，平均反应阈（ＡＢＲ）与对照组平均反应阈差异无显著性。（２）实验性内耳白身免疫性损害多导致可逆性听力障碍也可引起难以恢复的听力损害，并对可能机制进行了探讨。

Abstract Cuinea pogs were immunized repeatedly at four times by using a crude homologous inner earantigen(CIEAG)with an equal volume of complete or incomplete Freunds adjavant(CFA;IFA)injected subcutaneously. These animal models were through 9 weeks natural develooment. The results suggestsed that:(1)All animal models were recovered except one ear still had patho-logic changes in cochlear and two ears had hearing loss;(2 )The hearing threshold of experimental groups were no significant elevation that of the control groups;(3)The experimental autoimmune inner ear disorder may induced an reversible or irreversible sensorineural hearing loss.The patho-genesis were discussed