冠心病患者运动前后血浆内皮素水平变化的研究

CHANGES OF PLASMA ENDOTHELIN IN PATIENTS WITH CORONARY ARTERY DISEASE BEFORE AND AFTER EXCERSISE STRESS TEST

利用放射免疫测定技术检测了２０例已确诊冠心病的患者和１８个正常人在运动试验前、中、后的外周血内皮素（ＥＴ）水平。结果显示出冠心病患者与正常人在静息状态下血浆ＥＴ值比较无统计学意义（Ｐ＞０．０５）；运动后，冠心病者的血浆ＥＴ值呈逐渐的上升趋势，在１ｈ后最为显著（Ｐ＜０．００１）；而正常人在运动前后血浆ＥＴ值无明显变化（Ｐ＞０．０５）。并且经冠状动脉造影发现累及冠脉病变越严重（如多支病变），则运动后血浆ＥＴ值升高越明显。结论：对有冠状动脉疾病者应减少负荷性运动，避免ＥＴ分泌。

patients with coronary artery disease(CAD)confirmed by coronary angiography and 18 normal persons were tested for plasma endothelin levels before and after exercise stress tests by way of radioimmunoassay(RIA).The results suggested no statistical significance in plasma endothelin level changes in both groups before the tests(P>0.05).However,an increase of plasma endothelin levels was found in the CAD group during the tests,especially l hour after the tests started(P<0.001)while the control group showed no differences(P>0.05).It is also noticed in the tests that the plasma endothelin levels increase more significantly in patients with multiple coronary artery disease than in those with single coronary artery disease(P<0.001).The study suggests that patients with CAD take less overloading exercise to avoid the secretion and release of endothelin.