糙皮侧耳真菌糖肽口服对小鼠的抗瘤作用及其免疫学性质

Antitumor activity and effect on immunocompetence of Plurotus os-treatus fungi glycopeptides components by oral preparation in Mice

从糙皮侧耳真向中提取糖肽（ＰｌｕｒｏｔｕｓＯｓｔｒｅａｔｕｓＧｌｙｃｏｐｅｐｔｉｄｅｓ．ＰＯＧＰ），经超滤分出高、低分了组分（ＰＯＧＰ－Ｈ、ＰＯＧＰ－Ｌ），各组分分设高、低剂量组，对荷瘤Ｓ－１８０小鼠口服给药。结果ＰＯＧＰ－Ｈ高剂量组和ＰＯＧＰ－Ｌ低剂量组有显著抑瘤活性，且可促进ＬＡＫ活性和红细胞花环形成率。表明ＰＯＧＰ口服可吸收，低分子优于高分子，其作用与免疫系统有关。

OGPu were prepared from Plurotus Ostreatus fungi,advance fractionated by superfilter to high、lowmolecularweigtit components(POGP-H,POGP-L)Besides, high、low does groups were designed sepa-rately in the experiment.The resuIt shown that the antitumor activity after oral administion of highdose group on POGP-H and low does group on POGP-L were higher than in other group,it could en-hance the immunocompetence of erythrocytes.The above result appeared that POGP could be abeorbedby oral administion.futher more,low molecular weight fraction was higher than in high molecularweight fraction.