猪源杀菌性/通透性增加蛋白对烧伤大鼠绿脓杆菌菌血症的保护作用

Therapeutic effects of pig bactericidal/permeability increasing protein on septicemia after burns in rats 

目的：观察猪源杀菌性／通透性增加蛋白（ＢＰＩ）对大鼠烧伤绿脓杆菌菌血症的作用。方法：将８４只Ｗｉｓｔａｒ大鼠烧伤后经静脉注射绿脓杆菌悬液（１０６ｃｆｕｋｇ－１）随机分为烧伤绿脓杆菌菌血症组与烧伤绿脓杆菌菌血症ＢＰＩ（２ｍｇｋｇ－１）实验组，观察大鼠存活情况、全血细菌计数、血浆内毒素、血清ＴＮＦ－α、葡萄糖及乳酸浓度的改变。结果：保护组大鼠全血细菌计数、血浆内毒素、血清ＴＮＦ－α、葡萄糖浓度较对照组明显低。

Objective: To investigate the therapeutic effects of pig bactericidal/permeability increasing (BPI) protein on septicemia after burns in rats. Methods: After 84 rats were randomized into two groups of burned septicemia and BPI protein treatment, the levels of whole blood bacteria count, plasma endotoxin, serum TNF α, glucose and lactate were determined. Results: After treatment with BPI protein, the whole blood bacteria count and the levels of plasma endotoxin, serum TNF α, glucose and lactate were significantly decreased. Conclusion: BPI protein can exert marked therapeutic effects on septicemia after burns.