细胞外基质在人增殖性肾小球肾炎病变中的变化及意义

Changes of extracellular martix in human proliferative glomerulonephritis and its significance

目的：测定肾小球细胞外基质（ＥＣＭ）中透明质酸（Ｈｙａｌｕｒｏｎｉｃ，ＨＡ）、层粘蛋白（Ｌａｍｉｎｉｎ，ＬＮ）的含量变化，以探讨其在肾小球硬化机制中的作用。方法：采用放射免疫法对３２例肾小球肾炎患者和１５例正常肾组织进行测定。结果：肾组织中ＨＡ、ＬＮ和前胶原－３（ＰＣ－３）随病变进展明显增加。结论：ＨＡ。

Objcetive: To measure the contents of Hyaluronic (HA), Laminin (LN) and Procollagen type 3 (PC 3) in the extracellular matrix and to explore its effects in the mechanism of glomerulus cirrhosis. Methods: Thirty two proliferative glomerulonephritis patients and 15 cases of normal renal tissues were mesaured with radioimmunoassay. Results: HA, LN and PC 3 significantly increased. Conclusion: HA, LN and PC 3 play important roles in the mechanism of glomerulus cirrhosis.