经皮腔内冠状动脉成形术后血中内皮素与一氧化氮的变化

Changes of plasma levels of ET and NO after percutaneous transluminal coronary angioplasty

目的：探讨经皮腔内冠状动脉成形术（ＰＴＣＡ）后血中内皮素（ＥＴ）与一氧化氮（ＮＯ）的变化规律及意义。方法：对１５例接受ＰＴＣＡ治疗的冠心病患者及１２例单纯行冠状动脉造影者，分别于术前及术后１ｈ、３ｈ、２４ｈ取血标本，用放免法测定血ＥＴ浓度，用化学反应法测血ＮＯ含量。结果：ＰＴＣＡ后１ｈ、３ｈ血浆ＥＴ浓度较术前明显增高（Ｐ＜０．０５），而血中ＮＯ含量较术前明显降低（Ｐ＜０．０５），但两者均于ＰＴＣＡ后２４ｈ恢复至术前水平。结论：ＰＴＣＡ后血中ＥＴ与ＮＯ的正常平衡状态遭到破坏，有可能导致血管张力增加；因此。

Objective: To investigate the changes and significance of plasma endothelin (ET) and nitric oxide (NO) after percutaneous transluminal coronary angioplasty (PTCA). Methods: In the treated group (TG), 12 patients with coronary artery disease (CAD) received PTCA. In the control group (CG), 12 patients with CAD received coronary angiography. Using radioimmunoassay and chemical reaction assay, the concentrations of plasma ET and NO were determined before and at the 1st, 3rd and 24th h after operation. Results: The concentration of plasma ET was significantly increased (P<0.05) but that of plasma NO markedly decreased (P<0.05) at the 1st and 3rd h and both the two parameters returned to normal at the 24th h after PTCA. Conclusion: The disturbance of normal balance of ET and NO can induce increment of vascular stress after PTCA. Hence, it is necessary to prevent coronary artery spasm after PTCA.