低氧对雄性大鼠性腺的影响

Effects of hypoxia on the sexual gland of male rats

目的：研究低氧对雄性大鼠性腺的影响。方法：低压舱模拟海拔５ｋｍ和７ｋｍ高度，分别选择２４ｈ、７ｄ、２０ｄ为不同低氧暴露试验时间。结果：５ｋｍ组和７ｋｍ组低氧暴露２４ｈ后，雄性大鼠血浆睾丸酮（Ｔ）水平即有增高。低氧暴露７ｄ时，血浆Ｔ增至最高水平，尤以７ｋｍ组增高明显。连续２０ｄ低氧暴露发现，雄性大鼠血浆Ｔ水平却明显降低。此外，７ｄ、２０ｄ低氧暴露后，睾丸与其体重比明显增加。研究还发现长时间低氧暴露，可导致大鼠曲细精管间隙增大，管腔内各类细胞无序排列等形态学变化。急性及亚急性低氧暴露尚未发现睾丸组织形态明显变异。结论：急、慢性缺氧均影响受试动物性腺的功能。

AIM and METHODS: Effects of hypoxia on the sexual gland of male rats have been carried out by simulated altitude (5km and 7km) in the well-ventilated hypobaric pressur chamber for 24 hours, 7d and 20d, comparing with that at 2.3km of altitude.RESULTS:The ratio of rat testis to body weights increased with body wight decreasing in hypoxia exposed 7d and 20d both 5km and 7km groups. Especialy in 7km group, the body weight was suppressed obviously during 20d hypoxia exposure. Hypoxia exposed for 24 hours and 7d, the level of plasma testosterone of rats increased, especially in 7d increasing obviously. When hypoxia exposed for 20d, the level of plasma testosterone decreased sharply and the gaps among the seminiferous tubule enlarged compared whith 2.3km group. CONCLUSION: Acute and chronic hypoxia exposure effects the function of male rat sexual gland which responses to hypoxic stimuli quickly.