经肝动脉介入性热疗对犬肝功的影响

Effect of interventional thermotherapy through hepatic artery on liver function in dogs

目的 研究 6 0℃灌注液经肝动脉行灌注性热疗后 ,肝功各项指标的变化情况 ,为临床灌注性热化疗提供安全数据 .方法 经犬肝动脉 (n=10 )灌注入 6 0℃生理盐水 2 0 0m L ,30 min灌完 .分别于灌注前及灌注后 1,3,5 ,7d检查肝功的动态变化情况 .结果 DSA示肝动脉扩张 ,肝实质显影延迟 ;AL T,AST于灌注后开始升高 (AL T 10倍、AST 3倍 ) ,之后逐渐恢复 ,1wk后全部恢复正常 ,而胆红素、白蛋白及 γ-GT则无明显变化 .结论 经肝动脉 6 0℃介入性热疗对肝脏损伤轻微 。

AIM To evaluate the injury of interventional thermotherapy on liver tissue at 60℃ through hepatic artery. METHODS 200 mL saline at 60℃ was perfused through hepatic artery in 30 minutes. Liver function was checked before perfusion and 1,3, 5 and 7 days after the perfusion. RESULTS DSA indicated a little dilation of hepatic artery and delayed image of hepatic parenchyma. ALT, AST became abnormal (ALT 10 times, AST 3 times ) after the perfusion but reversed in a week, while BIL, ALB, γ GT indicated no significant changes at all. CONCLUSION Interventional thermotherapy at 60℃ through hepatic artery resultsin minor injury on liver tissues, so it is safe in clinical application.