外阴白斑和鳞癌细胞中p53蛋白的表达

p53 protein expression in genitalia luekoplakia and squamous cell carcinoma

目的 研究 p5 3蛋白对外阴白斑和鳞癌细胞中的表达 .方法 采用 ABC免疫组化法 ,对 10 2例外阴白斑和鳞癌患者进行 p5 3蛋白检测 .结果 各组与鳞癌组相比 ,经 χ2检验 ,有非常显著差别 (P<0 .0 1) .正常组 2 1例 χ2 =2 4.0 2 ,增生组 2 0例χ2 =9.2 3,硬化萎缩组 2 8例χ2 =5 3.2 3,混合组 2 3例 χ2 =138.39,不典型增生组 8例 χ2 =13.5 3.结论 p5 3蛋白的表达与鳞癌有密切关系 ,为肿瘤的恶性标志 ,说明 p5

AIM To study the expression of p53 protein in genitalia luekoplakia and squamous cells carcinoma. METHODS The genitalia luekoplakia and squamous cell carcinoma in 102 cases were detected with p53 protein by ABC immunohistochemical technique. RESULTS χ 2 test showed significant difference between the group of squamous cell carcinoma and the other groups of benign pathological changes: Normal group 21 cases, χ 2=24.02; hyperplasia type group 20 cases, χ 2=9.23; sclerotic atrophic type group 28 cases, χ 2=53.23; mixed type group 23 cases, χ 2=138.39; and atypical hyperplasia group 8 cases, χ 2=13.53 ( P <0.01). CONCLUSION Expression of the p53 protein correlates closely with the squamous cell carcinoma. The p53 protein expression implicates potential malignant transformation, which is a marker helpful in the differential diagnosis.