胺碘酮在治疗心房纤颤中增加QT离散度

Amiodarone increases QT dispersion in patients with atrial fibrillation

目的评价胺碘酮在治疗心房纤颤（房颤）中对心肌复极的影响。方法测量了４８例用胺碘酮转复与维持治疗房颤患者的ＱＴ问期与ＱＴ离散度，并与２１例阵发性房颤和４３例健康对照组比较。结果阵发性房颤组与健康组ＱＴ间期和ＱＴ离散度无差异（ＱＴ：４０５±４４ｖｓ３９７±３０，ＱＴｃ：４４８±４７ｖｓ４２４±２６，ＱＴＤ：２９±１７ｖｓ２７±１６，ＱＴｃＤ：２８±１９ｖｓ２６±１８，ｐ＞０．０５），但与前两对照组比，胺碘酮明显延长ＱＴ间期并使ＱＴＤ增大（ＱＴ：４６５±５３ｖｓ４０５±４４ｏｒ３９７±３０，ＱＴｃ：４９９±５４ｖｓ４４８±４７ｏｒ４２４±２６，ＱＴＤ：４７±２０ｖｓ２９±１７ｏｒ２７±１６，ＱＴｃＤ：４９±２１ｖｓ２８±１９ｏｒ２６±１８，Ｐ＞０．０１）。结论胺碘酮不仅延缓心肌复极，且使复极离散。

Objective This stUdy evaluated the effects of amiodarone on the myocardial repolarization in patients with atrialfibrillation. Methods QT intervals and QT dispersions measured from 12-lead standard surface ECG was retrospectively assessed in48 patients treated with amiodarone, and compared with that of paroxysmal atrial fibrillation and health groups. Results No disparityin QT interval and QT dispersion was found betWeen paroxysmal atrial fibrillation group and health group (QT: 405 ±44 vs 397± 30.QTc.448 ± 47 vs 424 ±26, QTD: 29 ± 17 vs 27 ± 16, QTcD: 28 ± 19 vs 26 ± 18, P>0.05), however, compared with these two groups,we tbund the QT interval and QT dispersion both significantly increase in amiodarone grouP(QT: 465 ± 53 vs 405 ± 44 or 397 ± 30,QTc. 499±54 vs 448±47 or 424±26, QTD: 47±20 vs 29± 17 or 27± 16, QTcD.49±21 vs 28±19 or 26±18, p<0.01).Conclusion Amiodarone can effectively control atrial fibrillation with QT interval prolongation and increase of QT dispersion.