月桂氮卓酮对无环鸟苷霜体外透皮吸作用的影响

Effect of Azone on the permeability of Acyclorior cream throught rabbit skin in vitro

本文以离体兔皮为渗透屏障,研究不同浓度氮酮对无环鸟苷的透皮促渗作用。结果表明,无环鸟苷霜的透皮吸收为零级动力学过程,氮酮对无环鸟苷的透皮促渗作用无浓度依赖性,经试验测得2％氮酮对无环鸟苷的促渗作用最强。

To investigate the effect of the different concentration of Azone on the Acyclorior (ACV)cream, We determined the Transdermal amount of the ACV and steady-state-rate of penetration in vitro, using the improved-Frenz cell and excised rabbit skin as transdermal barrier in permeation test. The result indicated transdermal absorption of ACV follwed zeroorder kinetics, and the penetration enhance effect of Azone was independent with the concertration. The ACV cream containing 2% Azone Showed remarkable effect to enhance the transdermal delivery amount of ACV.