摘要
对412例血药浓度测定结果进行了分析和总结。结果表明,412例病人中药物中毒者295例,占71.6%治疗药物浓度监测者117例,占28.4%。测定样本主要是血液。测定的药物共有5大类34种,其中为镇静催眠、抗焦虑药物中的苯二氮类最多,共计190例,占46.1%其次是抗精神病药物。中毒病人中以安定中毒者居首位,82例,占中毒病人的27.8%.其次为舒乐安定,27例,占9.2%.因舒乐安定的中毒浓度范围未定,故本文对测定的浓度进行了总结,发现其浓度在0.4~20.35μg/ml时(平均值2.99μg/ml)有中毒现象,但所有27例病人中无1例死亡,106例病人体内药物浓度达到中毒浓度,有17例病人属于混合药物中毒,其中以安定的混合率最大。治疗药物浓度监测最多的是氯丙嗪、氯氮平、卡马西平、茶碱等。
study analysed the results of blood drug concentrations determined in 412 patients,of which 295 (71.6%)were toxicosis patients and 117 (28.4%)TDM patients. The samples for determination mainly were serum. Thirty four drugs were measured, of which 46.1% was benzodiazepines. 82 patients were intoxicated by Valium and 27 by surazapamum. Because the toxic concentration of surazapamum in blood has not been established we analysed the results and found its toxic blood concentrations ranged form 0.4μg/ml to 20.35μg/ml with an average of 2.99μg/ml.27 patients showed toxicosis of suprazapamum, but no patient died.A total of 106 patients showed toxic blood concentrations of drugs,of which 17 patients were intoxicated by multiple drugs and Valium was the most common participant.The most commonly monitored therapentic drugs were chloropromazine, clozapine, carbamazepine and aminophylline etc.
出处
《中国药房》
CAS
CSCD
1995年第1期27-28,共2页
China Pharmacy
关键词
血药浓度
监测
药物中毒
回顾性分析
blood drug concentration monitoring drug intoxicosis retrospective analysis