412例血药浓度测定结果的回顾性分析

A Retrospective Analysis of Results of Blood Drug Concentration Determination in 412 Cases

对４１２例血药浓度测定结果进行了分析和总结。结果表明，４１２例病人中药物中毒者２９５例，占７１．６％治疗药物浓度监测者１１７例，占２８．４％。测定样本主要是血液。测定的药物共有５大类３４种，其中为镇静催眠、抗焦虑药物中的苯二氮类最多，共计１９０例，占４６．１％其次是抗精神病药物。中毒病人中以安定中毒者居首位，８２例，占中毒病人的２７．８％．其次为舒乐安定，２７例，占９．２％．因舒乐安定的中毒浓度范围未定，故本文对测定的浓度进行了总结，发现其浓度在０．４～２０．３５μｇ／ｍｌ时（平均值２．９９μｇ／ｍｌ）有中毒现象，但所有２７例病人中无１例死亡，１０６例病人体内药物浓度达到中毒浓度，有１７例病人属于混合药物中毒，其中以安定的混合率最大。治疗药物浓度监测最多的是氯丙嗪、氯氮平、卡马西平、茶碱等。

study analysed the results of blood drug concentrations determined in 412 patients,of which 295 (71.6%)were toxicosis patients and 117 (28.4%)TDM patients. The samples for determination mainly were serum. Thirty four drugs were measured, of which 46.1% was benzodiazepines. 82 patients were intoxicated by Valium and 27 by surazapamum. Because the toxic concentration of surazapamum in blood has not been established we analysed the results and found its toxic blood concentrations ranged form 0.4μg/ml to 20.35μg/ml with an average of 2.99μg/ml.27 patients showed toxicosis of suprazapamum, but no patient died.A total of 106 patients showed toxic blood concentrations of drugs,of which 17 patients were intoxicated by multiple drugs and Valium was the most common participant.The most commonly monitored therapentic drugs were chloropromazine, clozapine, carbamazepine and aminophylline etc.