SOD诱生剂对慢性氟中毒脑损伤的保护作用

Protective effect of SOD inducer on brain damage caused by chronic fluorosis

将ＳＯＤ诱生剂—绞股蓝复方制剂给予慢性氟中毒大鼠，观察其对慢性氟中毒脑损伤有无保护作用。实验发现：慢性氟中毒大鼠尿氟升高，骨及脑组织中明显氟蓄积，有氟斑牙形成。电镜体视学检查脑神经细胞呈变性。血尿素氮升高表明肾脏损伤。服用绞股蓝复方制剂的染氟大鼠，血清ＳＯＤ保持正常，血尿素氮正常，尿氟排出更多，而体内不再有氟蓄积。脑神经细胞无异常。结果表明：慢性氟中毒对发育成熟的大脑神经细胞有损伤作用。损伤机制可能与氟降低脑内ＳＯＤ水平，降低清除自由基能力有关。绞股蓝复方制剂则能诱使体内ＳＯＤ合成，保持体内正常ＳＯＤ水平，消除氟中毒时自由基对脑神经细胞的脂质过氧化损伤作用，同时保持肾功能，促进尿氟排除，消减脑氟蓄积，从而保护脑神经细胞不受损伤。

 Chronic fluorosis was reproduced in SD rats by drinking the water containing 48mg/L of F- and a SOD inducing drug,the Gynostemma Pentaphy11umherbal compound solution was given at the same time.Four months later,the animals were examined.In the animals with chronic fluorosis the serum SOD was lowered,the neurons of the brain showed degenerative changes.While in the animals drinking gthe water containing F- and treated with SOD inducing herb,the serum SOD was maintained within normal level,there was no F- deposite in the brain and neurons showed no abnormal changes.Our findings indicate that excessive fluorine may damage the brain cells by inhibiting SOD synthesis.Gynostemma Pentaphyllumherbal compound may promote the synthesis of SOD,exhibiting an antilipidperoxidation effect.Thus this SOD inducer exerts a protective effect on the brain,the kidneys and other tissues from rats with excessive fluorine.