银屑病患者全血和皮肤谷胱甘肽过氧化物酶活力关系的研究

Studies on GSH-Px activity of blood and skin in patients witn psoriasis

探讨了谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）与银屑病发病之间的关系。采用二巯基二硝基苯甲酸显色法，研究正常健康人和银屑病患者全血及皮肤ＧＳＨ－Ｐｘ活力的变化，结果表明，与正常健康人比较，银屑病患者全血和皮肤ＧＳＨ－Ｐｘ活力均明显降低（Ｐ＜０．００１，Ｐ＜０．０５），提示：ＧＳＨ－Ｐｘ活力的降低，特别是皮肤中ＧＳＨ－Ｐｘ活力的降低，可能是银屑病的重要原因之一。

Background/Aims:The etiology of psoriasis is unknown.The aim of this study was to investigate the relation between activity of glutathione peroxidase (GSH-Px)and psoriasis.Method:In psoriasis patients and healthy subjects,GSH-Px activity of blood and skin were measured by using 5,5'-dithio-bis 2-nitrobenzoic acid method.Results:In psoriasis patients GSH-Px activity of blood and skin were decreased than in healthy subjects(P<0001,P<005).Conclusions:Our results indicate that the decrease of GSH-Px activity may be one of the important factors which produce psoriasis.