异丙酚咪唑安定依托咪酯对小儿全麻诱导比较

Comparison of Propofol, Midazolam and Etomidate during Induction of Children's Anaethesia

目的 :比较异丙酚、咪唑安定和依托咪酯用于小儿全麻诱导作用。方法 :患儿 6 0例 ,ASAⅠ～Ⅱ级 ,随机分三组 ,分别给异丙酚 (P组 ) 2 .5mg·kg 1 ,依托咪酯 (E组 ) 0 .3mg·kg 1 ,咪唑安定 (M组 ) 0 .2mg·kg 1 。记录给药前、插管即刻、插管后 1,3 ,5 ,10min的心率、血压、脉搏氧饱和度。结果 :P组和M组的血压和心率变化不显著。E组的血压在插管即刻至插管 1,3min明显升高。结论 :三种药均可安全地用于小儿全麻诱导。

Objective:To compare the hemodynamic effects of propofol, midazolam and etomidate during induction in sick children. Methods: Sixty sick children were randomly divided into three groups to receive intravenous propofol 2.5 mg·kg -1 (group P), midazolam 0.2 mg·kg -1 (group M) or etomidate 0.3 mg·kg -1 (group E), respectively. All hemodynamic data were recorded before administration, during intubation and 1,3,5,10 min after intubation. Results: The Bp and HR had no change in group P and group M during whole procedure. In group E, the Bp had increased significantly at intubation to 1,3 min after intubation. Conclusion: propofol, midazolam and etomidate may be safely administrated for sick children during induction of anaesthesia.