吗啡硬膜外复合镇痛的临床观察

Clinical Observation of Combined Epidural Analgesia with Morphine

目的 :探讨一种能延长吗啡作用时间 ,减少副作用的镇痛方法。方法 :中下腹手术患者 10 0例 ,按镇痛液配方不同随机分为四组 ,均于手术结束前 5～ 10min经硬膜外注药。观察比较各组镇痛效果、作用时间及不良反应发生率。结果 :用高渗糖配制的镇痛液作用时间明显延长 (P <0 .0 1) ,辅用布比卡因和东莨菪碱后 ,不良反应发生率明显下降 (P <0 .0 5 )。结论 :吗啡辅用布比卡因及东莨菪碱 ,高渗糖溶液稀释后用于硬膜外术后镇痛 ,作用时间较长 ,副作用较少。

Objective: To investigate a method which could prolong the efficient time of morphine and decrease side effect. Methods: 100 patients were randomly divided into four groups, receiving the different dispensation of analgesia. Analgesic solutions were given into epidural space 5-10 minutes before operation was finished. Analgesic efficiency, efficient time, and side effects were recorded. Result: Solutions diluted with hypertonia glucose injection might prolong the efficient time obviously (P<0.01). When combined with bupivacaine or scopolamine the side effects were decreased. Conclusion: Morphine combined with bupivacaine or scopolamine diluted with hypertonis glucose injection, used in epidural analgesia, can bring longer efficient time and less side effects.