注射用阿奇霉素治疗细菌性感染59例

Efficency of Intravenous Azithromycin for Bacterial Infections in 59 Cases

目的 :评价注射用阿奇霉素治疗细菌性感染的疗效与安全性。方法 :采用随机对照多中心分组研究法 ,将 94例下呼吸道感染患者 ,随机分为两组 (每组 47例 )。治疗组用阿奇霉素 5 0 0mg加入 5 %葡萄糖注射液 5 0 0mL ,静脉滴注 ,qd ,5～ 7d为 1个疗程。对照组用乳糖酸红霉素 5 0 0mg加入 5 %葡萄糖注射液 5 0 0mL ,静脉滴注 ,bid ,5～ 7d为 1个疗程。开放组 12例 (4例盆腔炎和 8例下呼吸道感染 ) ,以阿奇霉素治疗。结果 :治疗组痊愈率 6 1.7%、有效率 91.5 %及细菌清除率 95 .8%均极显著高于对照组 (31.9% ,70 .2 % ,76 .6 % )。阿奇霉素治疗的 5 9例 ,总有效率 93 .2 % ,痊愈率6 2 .7%。试验组不良反应率 12 .8% ,显著低于对照组 (34.0 % )。结论

Objective: To evaluate the efficacy and safety of Azithromycin in the treatment of the bacterial infections. Methods: 94 patients with lower respiratory tract infection were randomly divided into 2 groups(47 for each gruop). The treated group were given Azithromycin 500mg in 5% glucose injection 500mL, iv drip, bid, for 5-7 days. Another 12 patients (including 4 patients with pelvic inflammatory disease and 8 patients with lower respiratory tract infection) were treated with Azithromycin as the open group. Results: The treated group yielded a recovery rate 61.7%, a effective rate 91.5% and a bacterial clearance rate 95.8%, which were higher than the controlled group [31.9%, 70.2%, and 76.6% (P<0.01)],respectively. The total response rate and the cure rate in 59 patients treated with Azithromycin were 93.2% and 62.7%, respectively. The incidence of clinical adverse drug reactions in the treated group was 12.8%, being lower than 34.0% in the controlled group (P<0.05). Conclusion: Azithromycin is an effective agent in the treatment of the acquired lower respiratory tract infection, urogenital and urogenital tract infection with slight adverse reaction.