茶碱血药浓度超出正常范围32例临床分析

Clinical Analysis of Serum Theophylline Level above Normal Therapeutical Range in 32 cases

目的 :对茶碱血药浓度超出正常治疗范围的 32例患者的临床表现进行分析。方法 :在 32 4例监测记录中选择血药浓度≥ 2 0 μg·mL 1 的患者 32例 ,结合临床进行分析。结果 :患者大部分都有较明显的毒副作用 ,包括心血管系统、消化系统、神经系统等方面的症状 ;>1 3的病例合用降低茶碱代谢药物。结论 :为有效预防毒副作用 ,正确判断病变与中毒 ,进行茶碱的血药浓度监测是必要的。

Objective: Clinical symptoms with serum theophylline level above normal therapeutical range were analysed in 32 case. Methods: Theophylline 20 μg·mL -1 invserum was defined as the upper limit of normal therapeutical range. The case records with serum theophylline concentraed ≥20 μg·mL -1 were selected from 324 cases, analysed in combination with clinical symptoms. Results: Patients with serum theophylline concentration ≥20 μg·mL -1 showed toxic reactions involving cardiovasucular, digestive, and nervous systems. One third of them took simultaneously other drugs which could decrease the metabolism of theophylline. Conclusion: In order to prevent and diagnose toxic reactions effectively, it's necessary to monitor the patients' serum theophylline level.