低分子肝素不同途径应用的效果研究

The effect study on the application of low molecule weight heparin by different approaches

目的探讨三种不同途径给予低分子肝素抗凝进行血液透析效果。方法采用单剂量一次性静脉端给药、单剂量一次性动脉端给药 ,先用低分子肝素总剂量中的 0 1ml预充体外循环后动脉端给同样剂量 ,每个病人用每种给药途径作三次透析、比较其有效性和安全性。结果三种方法给药 ,回血质量无差异 ,体外循环中均无凝血块出现 ,透后人工按压时间、部分凝血时间没有不同 (P >0 .0 5 )。结论静脉或动脉端给低分子肝素的安全性及有效性完全一样。

Objective To adopt three approaches of applying low molecule heparin as anticoagulant during blood hemodialysis.Method compare the safety and efficacy of the same dose of heparin by three injection approaches; one vein injection of single dose; one arteria injection of single dose; in vitro circulation pretreatment by 0 1?ml heparin then one arteria injection of single dose during henodialysis on each patient.Results There are no difference in the Quantity of blood reflux, there is no hard clot been found in invitro circulation there is no significant difference in pressing time and partial blood coagulation time(P>0.05) after hemodialysis.Conclusion The safety and efficacy is the same for heparin injection through Vein or arteria.