浙江省近年肾综合征出血热流行特征分析

Analysis of HFRS Epidemic in Zhejiang Province

目的 了解近年全省的流行规律 ,更好地制订 2 1世纪的防制措施 ,进一步降低发病率。方法 采用直接免疫荧光法 (FAT)检测鼠肺HV抗原 ;采用间接免疫荧光法 (IFAT)检测HFRS病人、健康人血清以及鼠血中HV抗体。结果 1997～ 1999年全省共发病 75 34例 ,年均发病率为 5 6 5 /10万 ,死亡 39人 ,病死率为 0 5 2 %。病例仍主要分布在沿钱塘江两岸的浙东和浙西丘陵区 ,浙南山区和浙北平原区次之 ,海岛区无病例 ,全省 11个地市中 10个地市有病人 ,以浙东和浙西丘陵区的绍兴、宁波、台州、衢州、杭州和金华六市发病最多 ,占全省病例总数的 87 44%。宿主动物野外以黑线姬鼠为优势种 ,占 80 2 4% ,室内以褐家鼠为优势种 ,占 85 0 0 %。全省鼠平均带病毒率为 3 2 8%。结论 要加强宁波等高发疫区的监测 ,同时推广接种HFRS疫苗。

Objective To Grasp HFRS's prevalent regularity in whole province, work out the way to deal with it in the new century. Method Useing direct Fluorescent Antibody Technic(FAT) to test HV antigen in rat's lung, and Indirect Fluorescent Antibody Technic(IFAT) to test HV antibody in serum of patient and people in good health.Result There were 7534 patients in whole province from 1997 to 1999,of which 39 died. The average incidence was 5 65 per 100?000 persons. Most patients were in the east and west hilly land of Zhejiang province. The patients were fund in 10 areas of Zhejiang provice. The patients were both dispersed and relatively concentrated. 87 44 percent of patient came from Shaoxing,Ningbo,Taizhou,Xuzhou,Hangzhou and Jinghua city. Most HFRS's host animal in field was Apodemus Agrarius Pallas, and most host animal in the house was Rattus Norvegicus Berkenhout.Conclusion HFRS's surveillance must be streng thened and vaccinating people with HFRS's vaccine should be promoted.