多烯康治疗儿童激素敏感型肾病综合征高脂血症疗效观察

Effects of Duoxikang in the Treatment of the Steroid Sensitive Nephrotic Syndrome Complicated by Hyperlipoidemia in Children

目的 观察糖皮质激素治疗后 (10周内 )多烯康治疗儿童激素敏感型肾病综合征 (SSNS)高脂血症的疗效。方法 SSNS患儿随机分为降脂治疗组 (治疗组 )和对照治疗组 (对照组 ) ,均给予糖皮质激素标准疗程 ,治疗组加用多烯康。分别在治疗前 ,治疗后 2～ 3周 ,5～ 6周 ,8～ 10周采空腹血观察 4种血脂成分 :总胆固醇 (TC) ,三酰甘油 (TG) ,高密度脂蛋白胆固醇 (HDL -C)和低密度脂蛋白胆固醇 (LDL C)。结果 疗程 2～ 3周治疗组LDL C(3 .19± 2 .0 8)mmol,TC(6 .42± 2 .0 4)mmol均显著低于对照组 (5 .82± 2 .73)mmol/L ,(10 .0± 4.75 )mmol/L ,(P均 <0 .0 5 )。第 5～ 6周治疗组LDL C(2 .83± 1.5 0 )mmol较对照组 (4 .94± 2 .0 4)mmol/L ,提前下降至低水平 (P <0 .0 1) ,第 8～ 10周治疗组LDL C(2 .30± 0 .46 )mmol仍明显低于对照组 (4 .2 0± 2 .2 2 )mmol/L ,(P <0 .0 1)。结论 多烯康能显著缩短SSNS严重高脂血症的时间 ,尤其是对降LDL C有显著疗效 。

Objective To investigate the therapeutic effect of Duoxikang capsula (DXK) on hyperlipoidemia in children with the steroid sensitive nephrotic syndrome (SSNS). Methods Twenty SSNS children were randomly divided into a DXK treated group and a control group. DXK was then administered (45 mg/kg weight daily) in the DXK treated group and the same regular steroid therapeutic measurements were conducted in two groups of SSNS. Blood lipoid compliments were determined, including total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL C) and low density lipoprotein cholesterol (LDL C) before the randomization, and again 2～3 weeks, 5～6 weeks, 8～10 weeks after the treatment. Results During the 2～3 weeks, levels of LDL C [( 3.19 ± 2.08 ) mmol and TC [( 6.42 ± 2.04 ) mmol] in the DXK treated group were markedly lower than those in the control group [( 5.82 ± 2.73 ) mmol, ( 10.0 ± 4.75 ) mmol, respectively] (both P< 0.05 ). During the 5～6 weeks and 8～10 weeks, the level of LDL C in the DXK treated group was also lower than that in the control group [( 2.83 ± 1.50 ) mmol vs ( 4.94 ± 2.04 ) mmol; ( 2.30 ± 0.46 ) mmol vs ( 4.20 ± 2.22 ) mmol, respectively. P< 0.01 ]. Conclusions DXK treatment reduced severe hyperlipoidemia, especially LDL C in children with SSNS. It is suggested that DXK treatment may reduce the secondary renal injury in these children.