各种脑活素中微量元素含量的比较

Contents comparison of trace elements in different cerebrolysins

目的 比较脑活素类生物制剂间各微量元素的含量差别 .方法 利用火焰原子吸收法直接测定 8种不同品牌的脑活素类生物制剂中镁、锰、铁、钴、镍、铜、锌和铬的含量 .结果 7种国产品牌制剂与奥地利脑活素比较 ,Mg,制剂间差异都非常显著 (P<0 .0 1) ;Mn,5种制剂差异非常显著 (P<0 .0 1) ,一种差异显著 (P<0 .0 5 ) ;Fe,4种制剂差异非常显著(P<0 .0 1) ,两种差异显著 (P<0 .0 5 ) ;Co,6种制剂差异非常显著 (P<0 .0 1) ;Ni,5种制剂差异非常显著 (P<0 .0 1) ;Cu,3种制剂差异非常显著 (P<0 .0 1) ,1种差异显著 (P<0 .0 5 ) ;Zn,制剂间差异都非常显著 (P<0 .0 1) ;Cr,3种制剂差异显著(P<0 .0 5 ) ;余者均无显著差异 (P>0 .0 5 ) .结论 本结果为临床合理用药提供了有用数据 .

AIM To compare the differences of contents of trace elements in cerebrolysin biological preparations. METHODS The contents of Mg, Mn, Fe, Co, Ni, Cu, Zn and Cr in eight kinds of cerebrolysin biological preparations were determined by flame atomic absorption spectrophotometry. RESULTS The contents of trace elements in seven kinds of cerebrolysin biological preparations made at home were compared with those made by Austria. The statistical results were as follows: in comparison with the control group the contents of Mg in all those cerebrolysin biological preparations had significant difference ( P <0.01); The contents of Mn in five cerebrolysin biological preparations had significant difference ( P <0.01), while one had a little difference ( P < 0.05 ); the contents of Fe in four biological preparations had significant difference ( P <0.01), while two had a little difference ( P <0.05); the contents of Co in six biological preparations had significant difference ( P <0.01); the contents of Ni in five biological preparations had significant difference ( P <0.01); the contents of Cu in three biological preparations had significant difference ( P <0.01) while one had a little difference ( P <0.05); the contents of Zn in seven kinds of biological preparations had significant difference ( P <0.01); the contents of Cr in three biological preparations had a little difference ( P <0.05). The rest had no significant difference ( P >0.05). CONCLUSION Useful data of cerebrolysin for administration in clinical practice are provided.