培哚普利治疗高血压病前后血浆内皮素和心钠素的变化

Changes of plasma endothelin and atrial antriuretic peptide in hypertensive patients with perindopril treatment

目的观察高血压病 ( EH)患者用培哚普利治疗前、后血浆内皮素 ( ET)和心钠素 ( ANP)的变化。方法 3 0例 EH患者用培哚普利治疗 4周 ,放免法测定治疗前后血浆 ET,ANP的浓度。另设正常对照组 3 0例。结果 EH患者用培哚普利血浆 ET、ANP水平明显高于对照组 ( P值均 <0 .0 1) ,经培哚普利治疗后 ,ET、ANP显著下降 ( P均 <0 .0 1)。结论培哚普利可降低 EH患者血浆 ET、ANP水平 ,从而有助于降低血压。

Objective To observe the effects of perindopril on changes of endothelin(ET)and atrial natriuretic peptide (ANP) in patients with essential hypertension (EH).Methods Thirty patients with EH were given with perindopril for four consecutive weeks.Plasma ET and ANP were examined with radioimmunoassay (RIA) before and after treatment,with thirty healthy volunteers as controls.Results Plasma levels of ET and ANP were higher in EH groups before treatment than those in controls (P<0.01),and decreased significantly after treatment than those before treatment (P<0.01).Conclusion The influence of perindopril on ET and ANP is correlated to its hypotensive effects in EH patients.