急性白血病患者凝血功能变化及其临床意义

Clinical significance of coagulation and fibrinolysis markers in patients with acute leukemia

目的 研究D 二聚体在急性白血病患者治疗前、后的变化及其临床意义。方法 采用ELISA方法测定 5 2例急性白血病患者的D 二聚体和纤溶酶原 (Plg)、α2 抗纤溶酶水平。结果 急性白血病患者初治者D 二聚体水平显著高于缓解者 ,在治疗后获缓解者水平显著高于未缓解者 ,复发者其水平要高于缓解时。结论 急性白血病患者体内存在明显的凝血、纤溶功能异常 ,D 二聚体是反应凝血功能的灵敏、特异性的标志物。监测凝血功能的变化 ,对白血病的诊断及预后有较大的临床意义。

Objective To investigate the therapy fore-and-aft varieties of D-dimer in acute leukemia patients.Methods The levels of D-dimer,α 2-plasminogen inhibitor and plasminogen were measured by ELISA in 52 patients with acute leukemia.Results The level of D-dimer of patients with acute leukemia was significantly higher than those in remission. When treated and remission, its level dropped to normal.Conclusion The acute leukemia patients have significant disorders of coagulation and fibrinolysis.To monitor the change of serum D-dimer might have clinical role in diagnosis and prognosis for patients with acute leukemia.